In the current global context, international economic relations have taken a predominant role for developing countries. This article offers an overview of the current state of the Central American Integration Process and its expansion into international markets, with a focus on trade relations with People’s Republic of China. Based on an analysis of the current macroeconomic conditions and a descriptive analysis of time series data of trade and Foreign Direct Investment (FDI) between 2014 and 2019, its growing commercial relationship with China and its geostrategic role in the continent, this paper analyses the opportunities and challenges of a Central America-China partnership with the intention to lay the foundations for the creation of a strategic trade and multilateral cooperation agenda that generates shared benefits for these countries.